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Postdoctoral Associate in Structural Biology

Position Information

Position Information:

Working Title: Postdoctoral Associate in Structural Biology
Faculty Rank: Postdoctoral Associate
Posting Number: SR0180001
About Virginia Tech:

Virginia Tech is a public land-grant university, committed to teaching and learning, research, and outreach to the Commonwealth of Virginia, the nation, and the world. Building on its motto of Ut Prosim (that I may serve), Virginia Tech is dedicated to InclusiveVT—serving in the spirit of community, diversity, and excellence. We seek candidates who adopt and practice the Principles of Community, which are fundamental to our on-going efforts to increase access and inclusion, and to create a community that nurtures learning and growth for all of its members. Virginia Tech actively seeks a broad spectrum of candidates to join our community in preparing leaders for the world.

Position Summary:


The Capelluto laboratory is looking for a Postdoctoral Associate candidate for structural biology, specifically in the design of a peptide to be employed to block platelet-cancer cell interactions. The Capelluto lab uses a combination of structural, biophysical, cell-based, and computational tools to establish how protein domains signal through membrane lipids.

Research Project: The successful candidate will contribute to a project, carried out in collaboration with Virginia Tech cell biologists, chemical engineers, and bioinformaticians, to develop peptides that will be able to bind to specific lipids at the platelet and leukemia cell surfaces to block platelet-leukemia cell interactions. We plan to use NMR and other structural approaches to assess the folding and stability of the peptides followed by their encapsulation to nanoparticles for delivery purposes. Nanocarriers will be evaluated using cell-cell adhesion assays and in endothelial cell-coated microfluidic devices.
The research will be conducted in the Capelluto laboratory of the Biocomplexity Institute at Virginia Tech. Our primary technique is solution-state NMR spectroscopy complemented by biophysical techniques, including surface plasmon resonance, circular dichroism, atomic force microscopy, isothermal calorimetry, and dynamic light scattering).

Required Qualifications:

Ph.D. in Structural Biology, Biophysics, Biochemistry or related field. Previous experience in NMR spectroscopy is required. Specifically, the candidate should be able to collect, process, and interpret NMR data. Experience in assigning protein NMR resonances is essential.

Preferred Qualifications:

Computational skills, including protein molecular docking.

Employment Conditions:
Must have a conviction check: Yes
Describe Other:
Employment Comments:
How to Apply for this Job:

Interested candidates should submit a curriculum vitae and a list of three references upon applying online at:, posting #SR0180001

For more information contact:
Daniel G. S. Capelluto, 

Associate Professor
Biological Sciences
Biocomplexity Institute
Virginia Tech

Employee Category: Research Faculty
Appointment Type: Restricted
If restricted or temporary, enter end date: 1 year contract, subject to renewal
FLSA Status: Exempt: Not eligible for overtime
Tenure Status: Non-Tenure Track
Academic Year or Calendar Year: Calendar Year
Percent Employment: Full-time
If part time, enter Percent Time:
Pay Band
Pay Range: 45,000 - 49,000 commensurate with experience
Department: Biological Sciences
Location: Blacksburg
Location, if not Blacksburg:
Location Zip Code: 24061
Job Posting Date: 01/10/2018
Review Begin Date: 01/24/2018
Job Close Date(if applicable):
Restricted to university employees only?
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For inquiries regarding non-discrimination policies, contact the executive director for Equity and Accessibility at 540-231-2010 or Virginia Tech, North End Center, Suite 2300 (0318), 300 Turner St. NW, Blacksburg, VA 24061.

Reasonable Accommodation Statement:

If you are an individual with a disability and desire accommodation please contact the hiring department.

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Required Documents

Required Documents
  1. Resume/Curriculum Vita
  2. List of References
Optional Documents
  1. Cover Letter